It is well known that next generation sequencing applications have led to numerous genomic discoveries that would otherwise have been improbable if not impossible. However, the number of genomes that have yet to be discovered is countless. The identity of these novel genomes is elucidated through De Novo Sequencing. Sequencing and assembly of novel genomes is only made possible with sufficient coverage of the genome of interest along with extended read lengths. While NGS has always offered researches deep sequencing capabilities, as the read length capabilities of next generation sequencers steadily increase, not only does De Novo Sequencing become more reliable, but it is also becomes more affordable. Integrating a seasoned laboratory staff with a bioinformatics team that has 20 years of continuous applied bioinformatics experience allows MR DNA to offer its customers a low cost sequencing solution, not only with regards to reference genomes, but novel genomes as well.